17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases

US8278469B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Wolfgang Schwede · Berlin, DE
• Ulrich Klar · Berlin, DE
• Carsten Möller · Berlin, DE
• Andrea Rotgeri · Berlin, DE
• Wilhelm Bone · Berlin, DE

Key dates

• Filing date: Dec 13, 2011
• Grant date: Oct 2, 2012
• Expiry date: Dec 13, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J41/0083
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of Formula I with progesterone antagonizing action and method of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of fibroids of the uterus (myomas, uterine leiomyoma), endometriosis, heavy menstrual bleeds, meningiomas, hormone-dependent breast cancers and complaints associated with the menopause or for fertility control and emergency contraception.