Nonalcoholic steatohepatitis model rodent and fatty liver model rodent
US8278499B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 13, 2007 |
| Grant date | Oct 2, 2012 |
| Priority date | — |
| Expiry date | Jun 13, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0362
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed is a nonhuman animal showing the symptoms of human nonalcoholic steatohepatitis which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal and then transplanting human hepatocytes that are propagated in the body of the chimeric nonhuman animal into an immunodeficient hepatopathic nonhuman animal of the same species as the immunodeficient hepatopathic nonhuman animal described above, as well as a nonhuman animal showing the symptoms of human fatty liver which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.