Method for determining thermal stability of collagen or collagen-like peptide
US8280710B2 · kind B2 · utility
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Key dates
| Filing date | Feb 3, 2006 |
| Grant date | Oct 2, 2012 |
| Priority date | — |
| Expiry date | Jul 17, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/1019
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is a method for determining the thermal stability of a collagen peptide, collagen-like peptide or triple-helix construct with the repeating peptide unit Gly-Xaa1-Xaa2. The instant method accounts for the destabilizing effect of peptide repeats which do not conform to the highly stable Gly-Pro-Hyp peptide and for the interaction between triplets. The instant method finds use in mutant analysis of collagen peptides, collagen-like peptides or triple-helix constructs and engineering of collagen peptides, collagen-like peptides or triple-helix constructs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.