Preparation of annexin derivatives
US8283167B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 4, 2010 |
| Grant date | Oct 9, 2012 |
| Priority date | — |
| Expiry date | Nov 27, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/087
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Labeled annexin is formed by reacting annexin or a modified annexin with a phosphatidylserine group or an analogue of phosphatidylserine. This phosphatidylserine annexin conjugate is then reacted with an appropriate label to form a labeled annexin and the annexin is separated from the phosphatidylserine group. The reaction between the phosphatidylserine group and the annexin is calcium ion concentration dependent. Therefore, the reaction can be promoted by having a high calcium ion concentration and the separation of the phosphatidyl group from the annexin group is facilitated by reducing the calcium ion concentration preferably by addition of an appropriate calcium chelating agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.