Withanolide compounds as inhibitors of fibrosis and identification of molecular targets for anti-fibrotic drug development
US8283323B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 13, 2007 |
| Grant date | Oct 9, 2012 |
| Priority date | — |
| Expiry date | Aug 22, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5038
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are methods for screening for drugs effective for treating fibrotic conditions. One screening method comprises exposing a cell to a test compound, monitoring the effect of the test compound on the amount or form of a cell molecule, comparing the amount or form of the cell molecule with the result obtained by treatment of the cell with an anti-fibrotic -effective amount of a withanolide compound, and selecting a drug effective for treating a fibrotic disease based on the ability of the test compound to provide the effect obtained by the withanolide compound on the cell molecule. Also provided is a method of treating a fibrotic disease comprising administering an anti-fibrotic effective amount of a withanolide compound to a mammal in need of treatment for fibrosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.