Ansamycin formulations and methods of use thereof

US8283343B2 · kind B2 · utility

Assignee

• Infinity Pharmaceuticals, Inc. · US

Inventors

• Brian C. Austad · Tewksbury, US
• Louis Grenier · Medford, US
• Edward Holson · Newton, US
• John J. Lee · Somerville, US
• Roger H. Pak · Boxborough, US
• James R. Porter · Rowley, US
• James L. Wright · Springfield, US

Key dates

• Filing date: Aug 20, 2008
• Grant date: Oct 9, 2012
• Expiry date: Aug 5, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D225/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Amorphous, polymorphic, and solvated forms of 17-amino geldanamycin are disclosed. These compounds are particularly useful for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and inhibiting Heat Shock Protein 90 (“Hsp90”).