2,4- Di(hetero)-arylamino-pyrimidine derivatives as ZAP-70 and/or SYK inhibitors

US8283356B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Rolf Baenteli · Basel, CH
• Marie Claude Bernhard · Wolschwiller, FR
• Peter Buehlmayer · Arlesheim, CH
• Nigel Graham Cooke · Oberwil, CH
• Rudolf Duthaler · Bettingen, CH
• Klaus Hinterding · Kohren-Sahlis, DE
• Gebhard Thoma · Lörrach, DE
• Maurice Van Eis · Buschwiller, FR
• Anette Von Matt · Basel, CH
• Louis Walliser · Basel, CH
• Gerhard Zenke · Rheinfelden (Baden), DE

Key dates

• Filing date: Jan 13, 2010
• Grant date: Oct 9, 2012
• Expiry date: Aug 28, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are pyrimidine derivatives of formulawherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.