Selective ligands for the dopamine 3 (D3) receptor and methods of using the same
US8283368B2 · kind B2 · utility
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Key dates
| Filing date | Aug 27, 2009 |
| Grant date | Oct 9, 2012 |
| Priority date | — |
| Expiry date | Aug 31, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.