Inhibitors of cytosolic phospholipase A2

US8283373B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• John C. McKew · Ames, US
• Katherine Lin Lee · Newton, US
• Lihren Chen · Cambridge, US
• Richard Vargas · Bedford, US
• James D. Clark · Acton, US
• Cara Williams · Methuen, US
• Valerie Clerin · Watertown, US
• Suzana Marusic · Reading, US
• Kevin Pong · Lawrence, US

Key dates

• Filing date: Jun 19, 2009
• Grant date: Oct 9, 2012
• Expiry date: Jun 19, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2α). In some embodiments, the inhibitors have the Formula I:wherein the constituent variables are as defined herein.