Patent · US Active

T cell receptor mutants

US8283446B2 · kind B2 · utility

33Cited by

1References

5Claims

0Family size

Assignee

IMMUNOCORE LIMITED · GB

Inventors

Bent Karsten Jakobsen · Abingdon, GB
Nathaniel Ross Liddy · Abingdon, GB

Key dates

Filing date	Aug 4, 2010
Grant date	Oct 9, 2012
Priority date	—
Expiry date	Nov 3, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A T cell receptor (TCR) having the property of binding to EVDPIGHLY HLA-A1 complex and comprising a specified wild type TCR which has specific mutations in the TCR alpha variable domain and/or the TCR beta variable domain to increase affinity. Such TCRs are useful for adoptive therapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.