Transgenic mouse models of Aβ overexpression

US8283517B2 · kind B2 · utility

Assignee

• PROBIODRUG AG · DE

Inventors

• Stephan Schilling · Halle (Saale), DE
• Holger Cynis · Dohnsen, DE
• Hans-Ulrich Demuth · Halle (Saale), DE
• Wolfgang Jagla · Windach, DE
• Sigrid Graubner · Munich, DE

Key dates

• Filing date: Sep 12, 2008
• Grant date: Oct 9, 2012
• Expiry date: Dec 12, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A transgenic non-human animal, in particular a transgenic mouse encoding Aβ peptide proteins, which have been implicated in Aβ peptide-related diseases. Cells and cell lines comprising transgenes encoding for Aβ peptide. Methods and compositions for evaluating agents that affect Aβ peptide, for use in compositions for the treatment of Aβ peptide-related diseases.