Nano-scale biosensors

US8283936B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Samir M. Iqbal · Euless, US
• Swati Goyal · Fremont, US
• Shawn M. Christensen · Arlington, US
• Mohammud R. Noor · Arlington, US

Key dates

• Filing date: Feb 8, 2010
• Grant date: Oct 9, 2012
• Expiry date: Apr 15, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/021
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Devices, systems, and methods for detecting nucleic acid hybridization, including single nucleic base mutations at low concentrations, are disclosed, using surface-tethered hairpin loop oligonucleotide probes and metal-nanoparticles conjugated to a hybridization detection sequence that is capable of binding the stem region of the opened hairpin loop oligonucleotide probe, without the use of labeling or target modification and capable of recycling.