Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination

US8287850B2 · kind B2 · utility

Assignee

• Fresenius Kabi Deutschland GmbH · DE

Inventors

• Wolfram Eichner · Rockenberg, DE
• Michele Orlando · The Hague, NL
• Norbert Zander · Marburg, DE
• Harald Conradt · Braunschweig, DE
• Frank Hacket · Schongau, DE
• Klaus Langer · Erlangen, DE
• Ronald Frank · Lehre, DE

Key dates

• Filing date: Sep 8, 2006
• Grant date: Oct 16, 2012
• Expiry date: Aug 22, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B31/185
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. Methods of producing these conjugates and specific uses of the conjugates also are provided.