Methods and means relating to protein variants
US8288123B2 · kind B2 · utility
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Key dates
| Filing date | Jan 5, 2006 |
| Grant date | Oct 16, 2012 |
| Priority date | — |
| Expiry date | Mar 30, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1041
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of providing a subject polypeptide variant with improved stability compared with a parent subject polypeptide, employing translation and selection using an RNA expression system, wherein two or more stability selection pressures are applied simultaneously during translation, two or more stability selection pressures are applied simultaneously during selecting, or at least one stability selection pressure is applied during translation and continues to be applied during selecting, and at least one further stability selection pressure is applied during selecting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.