Artificial immune system: methods for making and use

US8288159B2 · kind B2 · utility

Assignee

• Sanofi Pasteur Vaxdesign Corp. et al. · US

Inventors

• William L. Warren · Orlando, US
• Heather Fahlenkamp · Cleveland, US
• Russell Higbee · Orlando, US
• Anatoly Kachurin · Orlando, US
• Conan Li · Los Altos, US
• Mike Nguyen · Orlando, US
• Robert Parkhill · Orlando, US
• Guzman Sanchez-Schmitz · Orlando, US
• Darrell J. Irvine · Arlington, US
• Gwendalyn J. Randolph · New York, US
• Nir Harcohen · Brookline, US
• Bruce Torbett · Encinitas, US

Key dates

• Filing date: Mar 17, 2010
• Grant date: Oct 16, 2012
• Expiry date: Aug 11, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.