2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists

US8288435B2 · kind B2 · utility

Assignee

• Actelion Pharmaceuticals Ltd. · CH

Inventors

• Hamed Aissaoui · Allschwil, CH
• Christoph Boss · Allschwil, CH
• Markus Gude · Allschwil, CH
• Ralf Koberstein · Bad Kötzting, DE
• Thierry Sifferlen · Allschwil, CH
• Daniel TRACHSEL · Bern, CH

Key dates

• Filing date: Dec 28, 2007
• Grant date: Oct 16, 2012
• Expiry date: Apr 30, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.