Patent · US Active

Antibodies which bind and inhibit blood factor VIII

US8293234B2 · kind B2 · utility

1Cited by
18References
3Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 29, 2010
Grant dateOct 23, 2012
Priority date—
Expiry dateMar 29, 2030

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2317/70
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present invention discloses inhibitory antibodies against Factor VIII with modified glycosylation, either by enzymatic deglycosylation or by site directed mutagenesis. Said antibodies with modified glycosylation have equal affinity for FVIII but show different inhibiting properties. The use of one or a mixture of said antibodies allow modulation of the inhibition of factor VIII to levels between 40 and 95%. The present invention further discloses pharmaceutical compositions comprising inhibitory antibodies against Factor VIII with modified glycosylation, combinations of these antibodies and methods for treating haemostasis disorders using said antibodies and antibody mixtures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.