Polyglutamic acids functionalised by histidine derivatives and hydrophobic groups and the uses thereof, in particular for therapeutic purposes
US8293255B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 31, 2006 |
| Grant date | Oct 23, 2012 |
| Priority date | — |
| Expiry date | Jun 18, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/57
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel biodegradable materials based on modified polyamino acids and suitable, in particular, for vectoring active substance(s) (AS). Said invention also relates to novel pharmaceutical, cosmetic, dietary or plant protective compositions which are based on said polyamino acids.The aim of said invention is to provide a novel polymer raw material usable for vectoring the AS and capable to optimally meet all specification in this area: biocompatibility, biodegradability, ability to become easily associated with many active substances or to solubilize them and to release said active substances in vivo. The aim is attained to 30 carbon atoms.Said polyglutamates modified by histidine derivatives are soluble with pH lower than 5 and are easily and economically convertible into active substance vectorization particles which are able to form stable aqueous colloidal suspensions. On the contrary, said modified polyglutamates are insoluble in water with a physiological pH (7.4), and thereby have to be precipitated on an injection site in the case of a subcutaneous injection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.