Device for binding a target entity to a bait entity and detection methods using the same
US8293522B2 · kind B2 · utility
0Cited by
7References
39Claims
0Family size
Assignees
Inventor
Key dates
| Filing date | May 12, 2005 |
| Grant date | Oct 23, 2012 |
| Priority date | — |
| Expiry date | Jun 25, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4718
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention pertains to a device for binding a target entity onto a bait entity that is immobilized on said device, comprising: a) a lipid layer having a negative net charge in an aqueous solution at a neutral pH; b) a two-dimensional matrix of anchoring complexes that are bound to said lipid layer, wherein each of said anchoring complexes comprises: (i) a fusion complex comprising an Annexin protein fused to a partner molecule; and (ii) a bait entity. It also concerns various uses of said device, including for detection and pharmaceutical purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.