Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof

US8293739B2 · kind B2 · utility

Assignee

• Kinex Pharmaceuticals, LLC · US

Inventors

• David G. Hangauer, Jr. · East Amherst, US
• Daniel J. Coughlin · Lawrence, US
• Jonathan B. Gale · Townsend, US
• Jeremy A. Cody · Clifton Springs, US
• Debasis Patra · Manlius, US
• Grant J. Palmer · Clifton Park, US
• Paul K. Isbester · New York, US
• Jonathon S. Salsbury · Madison, US

Key dates

• Filing date: Apr 26, 2011
• Grant date: Oct 23, 2012
• Expiry date: Apr 26, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy) phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.