5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors

US8293757B2 · kind B2 · utility

Assignee

• IRM Inc. · BM

Inventors

• Valentina Molteni · San Diego, US
• Xiaolin Li · San Diego, US
• Xiaodong Liu · Beijing, CN
• Donatella Chianelli · San Diego, US
• Juliet Nabakka · San Diego, US
• Jon Loren · San Diego, US
• Shuli You · Shanghai, CN

Key dates

• Filing date: Aug 19, 2008
• Grant date: Oct 23, 2012
• Expiry date: Aug 19, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, AbI, BCR-AbI, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3. Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, Fms, KDR, c-rapor b-raf kinases.