Poly(lactide-co-glycolide) based sustained release microcapsules comprising a polypeptide and a sugar

US8293871B2 · kind B2 · utility

Assignees

• Alkernnes Pharma Ireland Limited · IE
• Amylin Pharmaceuticals, LLC · US

Inventors

• Steven G. Wright · Madeira, US
• Troy Christensen · Mason, US
• Thean Yeoh · Foxborough, US
• Michael E. Rickey · Morrow, US
• Joyce M. Hotz · Cincinnati, US
• Rajesh Kumar · Marlborough, US
• Henry R. Costantino · Woodinville, US
• Christine Smith · San Diego, US
• David M. Lokensgard · San Diego, US
• Mark S. Fineman · San Diego, US
• John Ong · Indianapolis, US

Key dates

• Filing date: Apr 15, 2005
• Grant date: Oct 23, 2012
• Expiry date: Apr 19, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.