Patent · US Active

Method for producing 3,7-diaza-bicyclo[3.3.1]nonane compounds

US8293910B2 · kind B2 · utility

0Cited by

7References

3Claims

0Family size

Assignee

Clariant Finance (BVI) Limited · VG

Inventors

Melanie Sajitz · Essen, DE
Steve Laborda · Hofheim, DE
Peter Naumann · Stockelsdorf, DE
Michael Wessling · Maintal, DE

Key dates

Filing date	Aug 17, 2009
Grant date	Oct 23, 2012
Priority date	—
Expiry date	Aug 17, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/08
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a one-pot reaction for the production of 3,7-diaza-bicyclo[3.3.1]nonane compounds, wherein in a first step a dicarboxylic acid ester is reacted with a pyridine aldehyde and a primary amine. The piperidone created in this manner is reacted with formaldehyde and a further primary amine in a second step. It is essential to the invention that both reaction steps are carried out in a one-pot variation in a C1-C4 alcohol as the solvent, and that the reaction water created is removed by means of distillation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.