Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators

US8293911B2 · kind B2 · utility

Assignee

• Valeant Pharmaceuticals International, Inc. · US

Inventors

• Jean-Michel Vernier · Laguna Niguel, US
• Martha Alicia De La Rosa · Morrisville, US
• Huanming Chen · Irvine, US
• Jim Zhen Wu · Shanghai, CN
• Gary Lee Larson · Cypress, US
• Ian Wayne Cheney · Port Coquitlam, CA

Key dates

• Filing date: Aug 22, 2007
• Grant date: Oct 23, 2012
• Expiry date: May 31, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a compound of formula IAwhere X═O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. They are potentially useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.