Multiplexing daughter ion spectrum acquisition from MALDI ionization
US8294086B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 17, 2008 |
| Grant date | Oct 23, 2012 |
| Priority date | — |
| Expiry date | Nov 17, 2029 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/0045
- WIPO fieldElectrical machinery, apparatus, energy
- WIPO sectorElectrical engineering
Abstract
The invention relates to the measurement of daughter ion spectra of analyte substances that are ionized by means of matrix-assisted laser desorption. The invention shows how to record several daughter ion spectra from several parent ions per single pulse of laser light, that is per desorption event, by spatially splitting the ion beams or by temporally sequencing the spectral measurement; the various parent ions are selected one after another by switching the parent ion selector several times. Summing up corresponding individual daughter ion spectra from many pulses of laser light leads to several sum spectra being recorded practically synchronously with the same series of laser light pulses, with correspondingly reduced sample consumption and shortened data acquisition time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.