Compositions and method for epigenetic modification of nucleic acid sequences in vivo
US8298529B2 · kind B2 · utility
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2References
11Claims
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Key dates
| Filing date | Apr 10, 2007 |
| Grant date | Oct 30, 2012 |
| Priority date | — |
| Expiry date | Jan 19, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilizing a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.