Patent · US Active

Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth

US8299046B2 · kind B2 · utility

49Cited by

22References

36Claims

0Family size

Assignees

TRUSTEES OF DARTMOUTH COLLEGE · US
Osteoscreen, Inc. · US
The Regents of the University of California · US

Inventors

Michael B. Sporn · Tunbridge, US
Karen T. Liby · Lebanon, US
Tadashi Honda · Kawasaki, JP
Gregory R. Mundy · San Antonio, US
Ross Garrett · Austin, US
Hari Reddi · El Macero, US
Gordon W. Gribble · Lebanon, US
Takahiro Niikura · Kobe, JP

Key dates

Filing date	Nov 16, 2007
Grant date	Oct 30, 2012
Priority date	—
Expiry date	Jun 12, 2028

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.