2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1H-pyrrol[3,2-C]pyridine-4(5H)-one compounds and use as protein kinase inhibitors

US8299069B2 · kind B2 · utility

Assignees

• JIANGSU HENGRUI MEDICINE CO., LTD. · CN
• SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. · CN

Inventors

• Peng Cho Tang · Moraga, US
• Jialiang Yang · Hangzhou City, CN
• Yidong Su · 安丰镇, CN
• Fuqiang Zhao · Chengdu, CN

Key dates

• Filing date: Jul 29, 2008
• Grant date: Oct 30, 2012
• Expiry date: Apr 12, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrrolo[3,2-c]pyridine-4-one-2-indolinone compounds, especially 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1H-pyrrol[3,2-c]pyridine-4(5H)-one compounds. Their preparation and pharmaceutical composition, and pharmaceutical use as protein kinase inhibitors.