2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors

US8299110B2 · kind B2 · utility

Assignee

• Pharmacyclics LLC · US

Inventors

• Aleksandr Kolesnikov · Mill Valley, US
• Roopa Rai · San Carlos, US
• William D. Shrader · Belmont, US
• Steven M. Torkelson · Lawrence, US
• Kieron E. Wesson · Menlo Park, US
• Wendy B. Young · San Mateo, US

Key dates

• Filing date: May 3, 2011
• Grant date: Oct 30, 2012
• Expiry date: May 3, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.