CCR10 antagonists

US8299123B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Kaka Dey · Latham, US
• Donghong Amy Gao · Hopewell Junction, US
• Daniel R. Goldberg · Redding, US
• Alexander Heim-Riether · Ingelheim am Rhein, DE
• John E. Mangette · Clifton Park, US
• Ingo Andreas Mugge · New Haven, US
• Roger John Snow · Danbury, US
• Alan David Swinamer · Bethel, US
• Jiang-Ping Wu · Lexington, US
• Zhaoming Xiong · Brookfield, US
• Yu Yang · Clark, US

Key dates

• Filing date: Oct 14, 2008
• Grant date: Oct 30, 2012
• Expiry date: Jan 25, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a compound of formula (I):or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.