Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof

US8299241B2 · kind B2 · utility

Assignee

• Arena Pharmaceuticals, Inc. · US

Inventors

• Tawfik Gharbaoui · Escondido, US
• Sagun Tandel · San Diego, US
• You-An Ma · Poway, US
• Marlon Carlos · Chula Vista, US
• John R. Fritch · Port Aransas, US

Key dates

• Filing date: Dec 4, 2007
• Grant date: Oct 30, 2012
• Expiry date: Dec 2, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D223/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides processes and intermediates for the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and salts thereof which are useful as serotonin-2C (5-HT2C) receptor agonists for the treatment of, for example, obesity.