Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use

US8299248B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Aaron Hinken · San Francisco, US
• Fady Malik · Burlingame, US
• Malar Pannirselvam · Foster City, US
• Alan J. Russell · Boulder, US

Key dates

• Filing date: May 14, 2010
• Grant date: Oct 30, 2012
• Expiry date: Oct 4, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are methods for treating myasthenia gravis in a patient, comprising administering to the patient an effective amount of at least one chemical entity chosen from compounds of Formula I and compounds of Formula II:and pharmaceutically acceptable salts thereof.