Methods for preparing diazonamides

US8299268B2 · kind B2 · utility

Assignees

• The Board of Regents of the University of Texas System · US
• Joyant Pharmaceuticals, Inc. · US

Inventors

• Gunnar J. Hanson · Cambridge, US
• Charles G. Caldwell · Dallas, US
• Patrick G. Harran · Dallas, US
• Susan Harran · Dallas, US
• Qi Wei · Dallas, US
• Ming Zhou · Coppell, US

Key dates

• Filing date: Jul 19, 2011
• Grant date: Oct 30, 2012
• Expiry date: Jul 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to novel macrocyclic lactams intermediates useful for the preparation of diazonamide analogs. This invention also relates to a novel electrochemical oxidative cyclization for the preparation of such macrocyclic lactams, and their further elucidation to provide diazonamide analogs.