Patent · US Active

Process for preparing α-keto acids and derivatives thereof

US8299293B2 · kind B2 · utility

2Cited by

3References

20Claims

0Family size

Assignee

EVONIK DEGUSSA GMBH · DE

Inventors

Christoph Kobler · Alzenau, DE
Martin Hateley · Aschaffenburg, DE
Philipp Roth · Baden, CH
Barbara Jaeger · Seligenstadt, DE
Christoph Weckbecker · Gelnhausen, DE
Klaus Huthmacher · Gelnhausen, DE

Key dates

Filing date	Jul 9, 2008
Grant date	Oct 30, 2012
Priority date	—
Expiry date	Jul 2, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D493/08
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A method for preparing α-keto acids, especially α-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting α,α-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the α-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.