Compositions and methods relating to proteins requiring gamma-carboxylation
US8304224B2 · kind B2 · utility
5Cited by
18References
28Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 23, 2011 |
| Grant date | Nov 6, 2012 |
| Priority date | — |
| Expiry date | Jun 23, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/64
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a γ-glutamyl carboxylase and associated control sequences. The invention further relates to a method of producing a protein requiring gamma-carboxylation in high yields.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.