Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids
US8304252B2 · kind B2 · utility
2Cited by
5References
7Claims
0Family size
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Key dates
| Filing date | Apr 20, 2010 |
| Grant date | Nov 6, 2012 |
| Priority date | — |
| Expiry date | Aug 14, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/207497
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to a regio-and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.