Identification of a micro-RNA that activates expression of β-myosin heavy chain
US8304397B2 · kind B2 · utility
10Cited by
2References
34Claims
0Family size
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Key dates
| Filing date | Jul 31, 2007 |
| Grant date | Nov 6, 2012 |
| Priority date | — |
| Expiry date | Aug 4, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of β-myosin heavy chain (β-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.