Hedgehog signaling pathway proteins and uses thereof
US8304399B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | Nov 9, 2007 |
| Grant date | Nov 6, 2012 |
| Priority date | — |
| Expiry date | Nov 22, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a component in the hedgehog signaling pathway that can be useful in the treatment and diagnosis of hedgehog signaling pathway associated disorders. In this regard, the present invention discloses that RanBPM regulated the stability of hedgehog signaling molecule, smoothened (SMO) and that inactivation of RanBPM by siRNA prevented growth and metastasis of cancer cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.