Pyrazolone derivatives as PDE4 inhibitors

US8304436B2 · kind B2 · utility

Assignee

• NYCOMED GMBH · DE

Inventors

• Beate Schmidt · Allensbach, DE
• Christian Scheufler · Bad Liebenzell, DE
• Juergen Volz · Radolfzell, DE
• Martin Feth · Kelkheim, DE
• Rolf-Peter Hummel · Radolfzell, DE
• Armin Hatzelmann · Konstanz, DE
• Christof Zitt · Konstanz, DE
• Andrea Wohlsen · Konstanz, DE
• Degenhard Marx · Radebeul, DE
• Hans-Peter Kley · Allensbach, DE
• Deborah Ockert · Hamburg, DE
• Anke Heuser · Hamburg, DE
• Johannes A. M. Christiaans · Lelystad, NL
• Geert Jan Sterk · Utrecht, NL
• Wiro M. P. B. Menge · Oosterbeek, NL

Key dates

• Filing date: May 14, 2008
• Grant date: Nov 6, 2012
• Expiry date: Jun 20, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compounds of a certain formula 1,in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.