Patent · US Active

Process for the manufacture of an indolinone derivative

US8304541B2 · kind B2 · utility

3Cited by

1References

9Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

Joern Merten · Heidesheim, DE
Guenter Linz · Mittelbiberach, DE
Juergen Schnaubelt · Biberach, DE
Rolf Schmid · Gelterkinden, CH
Werner Rall · Mittelbiberach, DE
Svenja Renner · Eckenroth, DE
Carsten Reichel · Rheinböllen, DE
Robert Schiffers · Gau-Algesheim, DE

Key dates

Filing date	Dec 2, 2008
Grant date	Nov 6, 2012
Priority date	—
Expiry date	Nov 2, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D209/34
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.