In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate or nanoparticulate active agent compositions

US8309136B2 · kind B2 · utility

Assignee

• Alkermes Pharma Ireland Limited · IE

Inventors

• Eugene R. Cooper · Cincinnati, US
• John Bullock · King of Prussia, US
• John R. Chippari · Phoenixville, US
• John L. Schaefer · Gilbertsville, US
• Rakesh Patel · Chicago, US
• Rajeev Jain · Framingham, US
• Joost Strasters · Exton, US
• Niels P. Ryde · Malvern, US
• Stephen B. Ruddy · Schwenksville, US

Key dates

• Filing date: Mar 22, 2010
• Grant date: Nov 13, 2012
• Expiry date: Jun 12, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1623
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions.