Drug delivery matrices to enhance wound healing
US8309518B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 28, 2010 |
| Grant date | Nov 13, 2012 |
| Priority date | — |
| Expiry date | Jul 28, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/45
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through precipitation of the bioactive molecule during gelation of the matrix, either in vitro or in vivo. The bioactive molecule may be modified to reduce its effective solubility in the matrix to retain it more effectively within the matrix, such as through the deglycosylation of members within the cystine knot growth factor superfamily and particularly within the TGFβ superfamily. The matrix may be modified to include sites with binding affinity for different bioactive molecules, for example, for heparin binding.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.