Implant improving local bone formation
US8309536B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Sep 24, 2010 |
| Grant date | Nov 13, 2012 |
| Priority date | — |
| Expiry date | Sep 24, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/602
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase rapidly releases a first quantity of the active agent, and at least a second phase gradually releases a second quantity of the active agent, whereby bone formation stimulated by the active agent is modulated. In one embodiment, a porous implant comprises a porous portion coated with a calcium phosphate compound and which is contacted with a bisphosphonate compound to form a bisphosphonate layer chemically bound to the calcium phosphate at the surface of the porous portion and to form bisphosphonate molecules being non-chemically attached inside the pores of the porous portion. The non-chemically attached bisphosphonate molecules are released in the subject at a rate greater than that of the chemically bound bisphosphonate layer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.