Kallikrein 7 modulators

US8309596B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Stefanie Flohr · Basel, CH
• Stefan Andreas Randl · Frankfurt am Main, DE
• Nils Ostermann · Binzen, DE
• Ulrich Hassiepen · Bad Kötzting, DE
• Frederic Berst · Altkirch, FR
• Ursula Bodendorf · Basel, CH
• Bernd Gerhartz · Bad Kötzting, DE
• Andreas Marzinzik · Weil, DE
• Claus Ehrhardt · Lörrach, DE
• Josef Gottfried Meingassner · Wien, AT

Key dates

• Filing date: Jun 26, 2008
• Grant date: Nov 13, 2012
• Expiry date: Jan 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2299/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the crystal structure of the serine protease kallikrein 7 and to the use of this crystal structure in drug discovery. The present invention also relates to compounds binding specifically to this active site of kallikrein 7.