Multi-substituted diarylanilines as non-nucleoside HIV reverse transcriptase inhibitors, and preparation and use thereof

US8309602B2 · kind B2 · utility

Assignees

• Institute of Pharmacology and Toxicology · CN
• Academy of Military Medical Sciences · CN

Inventors

• Lan Xie · Chapel Hill, US
• Bingjie Qin · Beijing, CN
• Kuo-Hsiung Lee · Chapel Hill, US
• Shibo Jiang · Floral Park, US
• Hong Lu · Des Moines, US

Key dates

• Filing date: Oct 7, 2008
• Grant date: Nov 13, 2012
• Expiry date: May 20, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to multi-substituted m-diarylanilines or pharmaceutically acceptable salts thereof, wherein X, R1-R7 are as defined in the claims, their preparation process, pharmaceutical compositions comprising them and their use for the manufacture of a medicament for anti-HIV.