Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride

US8309610B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Michael Gruss · Aachen, DE
• Helmut Buschmann · Walheim, DE
• Andreas Fischer · Castro Valley, US
• Wolfgang Hell · Aachen, DE
• Dagmar Lischke · Eschweiler, DE

Key dates

• Filing date: Feb 21, 2006
• Grant date: Nov 13, 2012
• Expiry date: Mar 6, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.