Methods and compositions for enhancing the efficacy and specificity of RNAi
US8309704B2 · kind B2 · utility
62Cited by
6References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 2, 2004 |
| Grant date | Nov 13, 2012 |
| Priority date | — |
| Expiry date | Dec 29, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/50
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods of enhancing the efficacy and specificity of RNAi. The invention also provides compositions for mediating RNAi. In particular, the invention provides siRNAs, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.