Methods and compositions for enhancing the efficacy and specificity of RNA silencing
US8309705B2 · kind B2 · utility
67Cited by
6References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 29, 2010 |
| Grant date | Nov 13, 2012 |
| Priority date | — |
| Expiry date | Apr 17, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.