HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof

US8309721B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Jean-Marie Ruxer · Paris, FR
• Victor CERTAL · Paris, FR
• Marcel Alasia · Paris, FR
• Luc Bertin · Étampes, FR
• Herve Minoux · Thiais, FR
• Patrick Mailliet · Fontenay-sous-Bois, FR
• Frank Halley · Romford, GB
• Maria MENDEZ-PEREZ · Frankfurt am Main, DE

Key dates

• Filing date: Sep 14, 2010
• Grant date: Nov 13, 2012
• Expiry date: Sep 14, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R′1; R is selected from the group comprising Formula (A′), (B), (C), (D), or (E), with R1 and/or R′1 selected from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalcoxy, alkylhio, or carboxy that is free or esterified by an alkyl, carboxamide, CO—NH(alkyl), CON(alkyl)2, NH—CO-alkyl, sulfonamide, NH—S02-alkyl, S(0)2-NHalkyl, or S(02)-N(alkyl)2 radical; all these radicals are optionally substituted; W1, W2, and W3 independently are CH or N; X is 0, S, NR2, C(O), S(O), or S(0)2; Z is optionally substituted H, Hal, -0-R2 or —NH—R2 with R2 being H, alkyl, cycloalkyl, or heterocycloalkyl; and these substances are all isomeric forms and salts thereof, used as drugs.