Opiate reduction utilizing catalytic hydrogen transfer reaction
US8309727B2 · kind B2 · utility
10Cited by
23References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 15, 2008 |
| Grant date | Nov 13, 2012 |
| Priority date | — |
| Expiry date | Jul 29, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved opiate synthesis scheme is provided. An improvement to the oxidation of oripavine and oripavine derivatives comprises the in-situ formation of the peroxacids required to oxidize the oripavine and oripavine derivatives to form an intermediate. An improvement to the reduction of the intermediate to form oxycodone and oxycodone derivatives comprises reduction utilizing a hydrogen transfer reagent. These improvements allow the production of oxycodone and oxycodone derivatives without isolation of the intermediate, providing a one-pot synthesis method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.